Pro-inflammatory activated Kupffer cells by lipids induce hepatic NKT cells deficiency through activation-induced cell death.
BACKGROUND: Dietary lipids play an important role in the progression of non-alcoholic fatty liver disease Oyster Knives (NAFLD) through alternation of liver innate immune response.AIMS: The present study was to investigate the effect of lipid on Kupffer cells phenotype and function in vivo and in vitro.And further to investigate the impact of lipid